Drug treatments for covid-19: living systematic review and network meta-analysis
SARS-CoV-2 Clinical Update: Virology, Transmission & Pathogenesis
Respiratory virus shedding in exhaled breath and efficacy of face masks
Face masks are effective in preventing spread of infection. However, it should not be used as the only method. LINK Nature
Covid-19: What is the evidence for cloth masks?
As the US Centers for Disease Control and Prevention has advised all Americans to wear cloth masks in public to prevent the spread of covid-19. LINK The BMJ examines the evidence
Why is cardiovascular disease (CVD) so prevalent in those who died with COVID-19?
Italian National Institute of Health analysed 355 fatalities and found only three patients (0.8%) had no prior medical conditions. The most common problems in the 355 who died were: 76% high blood pressure; 36% diabetes, and 33% ischemic heart disease.
The reason why this happens – most acute viral infections have three short-term effects on the cardiovascular system: the inflammatory response can increase the risk of an acute coronary syndrome; depression of the myocardium can worsen heart failure, and inflammation can unmask heart arrhythmias.
Chloroquine and hydroxychloroquine in treatment of COVID-19
LINK BJGP April 8 in a rapid review – “At present, there is insufficient evidence to determine whether CQ/HCQ are safe and effective treatments for COVID-19. High quality, adequately powered randomised clinical trials in primary and secondary care settings are urgently required to guide policymakers and clinicians”
The Primary Care Clinical Trials Unit of the Oxford University has started recruiting patients for the first RCT UK
The PRINCIPLE trial aims to find out whether selected treatments given to people at higher risk of becoming more ill when they are infected with COVID-19 can help reduce the need for hospitalisation and the length of stay required, helping people recover quicker and with fewer complications. The trial is recruiting participants through GP practices across the UK.
To obtain a overview and some fundamental aspects of COVID-19 please listen to,
Perspectives on the Pandemic | Dr John Ioannidis of Stanford University | Episode 4
(1.15 hrs You Tube interview below)
The current up to date evidence-based status of the CORONA-19 pandemic as at 20 April
Prof Ioannidis is Prof of Medicine at Stanford University who has the higest number of
Coronavirus disease 2019: The harms of exaggerated information and non-evidence-based measures.